学术报告 1
Foodstuffs for preventing cancer: the preclinical and
clinical development of berries.
用于预防癌症的食品：浆果的临床前和临床开发
原文链接官方网址：https://www.ncbi.nlm.nih.gov/pubmed
Cancer Prev Res (Phila). 2009 Mar;2(3):187-94. doi: 10.1158/1940-6207.CAPR-08-0226. Epub 2009 Mar
3.
癌症前列腺癌（Phila）。 2009 年 3 月; 2（3）：187-94。doi：10.1158 / 1940-6207.CAPR-08-0226。电子杂
志 2009 年 3 月 3 日。
Department of Internal Medicine, The Ohio State University, Innovation Centre,
2001 Polaris Parkway, Columbus, Ohio 43240, USA. gary.stoner@osumc.edu
美国俄亥俄州立大学内科医学系创新中心，美国俄亥俄州 43240，哥伦布，北极星大路 2001 号。gary.stoner@osumc.edu
Laboratory research involving berries is a promising example of food-based cancer prevention. Berries contain many known chemopreventive agents such as anthocyanins and ellagitannins that can be greatly concentrated in freeze-dried berry powders. Based on our program of berry research, this commentary presents the first reported stepwise scheme for the preclinical and clinical development of
foodstuffs for cancer prevention. Our preclinical work within this scheme includes
promising approaches for assessing the chemopreventive potential of berry powder and berry extracts in preclinical model systems, for determining the mechanisms of action of these agents, and for identifying the active constituents in berries. The commentary also presents preliminary results of clinical trials in the oral cavity, esophagus, and colon using various formulations of freeze-dried berries. The relative merits of berry powders, extracts, or individual constituents (anthocyanins) for cancer prevention are also discussed.
涉及浆果的实验室研究是以食物为基础的癌症预防的有希望的例子。浆果含有许多已知的化 学预防剂，例如花青素和鞣花单宁，它们可以大量浓缩在冻干浆果粉中。根据我们的浆果研 究计划，本评论介绍了用于癌症预防食品的临床前和临床开发的第一个已报告的逐步计划。 我们在该方案中的临床前工作包括评估浆果粉和浆果提取物在临床前模型系统中的化学预 防潜力，确定这些药物的作用机制以及确定浆果中活性成分的有前途的方法。评论还介绍了 临床试验在口腔，食道，和使用冷冻干燥浆果的各种制剂的结肠。还讨论了浆果粉，提取物 或单个组分（花青素）对癌症预防的相对优点。
PMID:19258544
DOI:10.1158/1940-6207.CAPR-08-0226
源自：
美国国家医学图书馆
美国国家卫生研究院
US National Library of Medicine/
Us National Institutes of Health/
企业亮照