学术报告 10

Topical treatment with black raspberry extract reduces cutaneous UVB-induced carcinogenesis and inflammation.

黑覆盆子提取物局部治疗可减少皮肤 UVB 诱导的癌变和 炎症。

原文链接官方网址：https://www.ncbi.nlm.nih.gov/pubmed

Cancer Prev Res (Phila). 2009 Jul;2(7):665-72. doi: 10.1158/1940-6207.CAPR-08-0193.

癌症前列腺癌（Phila）。2009 年 7 月; 2（7）：665-72。doi：10.1158 / 1940-6207.CAPR-08-0193。

Duncan FJ1, Martin JR, Wulff BC, Stoner GD, Tober KL, Oberyszyn TM,   Kusewitt

DF, Van Buskirk AM.

 Author information

Department of Pathology, The Ohio State University, 1645 Neil Avenue, 129  Hamilton

Hall, Columbus, OH 43210, USA.

作者信息 

美国俄亥俄州立大学病理系，1645 尼尔大街，129 哈密尔顿大厅，哥伦布，俄亥俄州 43210，

美国。

Abstract

Light in the UVB spectrum (280-320 nm) induces a number of changes in the epidermis and dermis of mice and humans, resulting in a robust inflammatory response. A standardized black raspberry extract (BRE) has been effective in

reducing signaling pathways commonly initiated by inflammatory stimuli. In this

study, we determined whether this extract could reduce cutaneous UVB-induced inflammation and carcinogenesis. In our carcinogenesis model, female SKH-1 hairless mice were exposed to one minimal erythemal dose of UVB thrice weekly on nonconsecutive days for 25 weeks. Immediately after each exposure, the mice were treated topically with either BRE dissolved in vehicle or with vehicle only. Beginning on week 19, mice treated with BRE had a significant reduction in tumor number and in average tumor size. This reduction correlated with a significant reduction in tumor-infiltrating CD3(+)foxp3(+) regulatory T-cells. In the acute model, mice were exposed to a single minimal erythemal dose of UVB and treated topically with BRE or with vehicle. At 48 hours post-UVB exposure, topical BRE treatment significantly reduced edema, p53 protein levels, oxidative DNA damage, and neutrophil activation. The ability of topical BRE to reduce acute UVB-induced inflammation and to decrease tumor development in a long-term model provides compelling evidence to explore the clinical efficacy of BRE in the prevention of human skin cancers.

UVB 光谱（280-320nm）中的光诱导小鼠和人的表皮和真皮发生许多变化，导致强烈的炎症反 应。标准黑覆盆子提取物（BRE）已经有效地减少了通常由炎性刺激引发的信号传导途径。在这 项研究中，我们确定这种提取物是否可以减少皮肤 UVB 诱导的炎症和癌变。在我们的癌发生模 型中，雌性 SKH-1 无毛小鼠在非连续日每周三次暴露于一次最小红斑剂量的 UVB 25 周。紧接 着每次暴露后，将小鼠局部用 BRE 溶于载体或仅用媒介物处理。从第 19 周开始，用 BRE 治疗

或载体局部处理。在 UVB 暴露后 48 小时，局部 BRE 治疗显着降低水肿，p53 蛋白水平，氧化

性 DNA 损伤和嗜中性粒细胞活化。局部 BRE 在长期模型中减少急性 UVB 诱导的炎症和减少肿 瘤发展的能力提供了令人信服的证据，以探索 BRE 在预防人类皮肤癌中的临床功效。局部 BRE 治疗显着降低水肿，p53 蛋白水平，氧化性 DNA 损伤和嗜中性粒细胞活化。局部 BRE 在长期 模型中减少急性 UVB 诱导的炎症和减少肿瘤发展的能力提供了令人信服的证据，以探索 BRE 在 预防人类皮肤癌中的临床功效。局部 BRE 治疗显着降低水肿，p53 蛋白水平，氧化性 DNA 损 伤和嗜中性粒细胞活化。局部 BRE 在长期模型中减少急性 UVB 诱导的炎症和减少肿瘤发展的能 力提供了令人信服的证据，以探索 BRE 在预防人类皮肤癌中的临床功效。

PMID:19584078  

DOI:10.1158/1940-6207.CAPR-08-0193

源自：

美国国家医学图书馆

美国国家卫生研究院

US National Library of Medicine/

Us National Institutes of Health/