学术报告 2
Black Raspberry Extract Increased Circulating Endothelial
Progenitor Cells and Improved Arterial Stiffness in Patients with Metabolic Syndrome: A Randomized Controlled Trial.
黑覆盆子提取物增加循环内皮祖细胞和改善动脉僵硬度在代谢综合 征患者：一项随机对照试验。
原文链接官方网址：https://www.ncbi.nlm.nih.gov/pubmed
J Med Food. 2016 Apr;19(4):346-52. doi: 10.1089/jmf.2015.3563. Epub 2016 Feb 18.
J Med 食品。2016 年 4 月; 19（4）：346-52。doi：10.1089 / jmf.2015.3563。电子 书 2016 年 2 月 18 日。
Jeong HS1, Kim S1, Hong SJ1, Choi SC1, Choi JH1, Kim JH1, Park CY1, Cho JY1, Lee TB2, Kwon JW2, Joo HJ1, Park JH1, Yu CW1, Lim DS1.
Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital , Seoul, Korea.
Gochang Black Raspberry Research Institute , Gochang, Korea.
郑某 HS 1，金小号 1，香港 SJ 1，财 SC 1，财 JH 1，金 JH 1，公园 CY 1，卓 JY 1， 李 TB 2，权 JW 2，朱 HJ 1，公园 JH 1，俞 CW 1，Lim DS 1。
韩国首尔韩国大学 Anam 医院心血管中心心内科。
高敞黑 覆盆子研究所，韩国高昌。
Administration of black raspberry (Rubus occidentalis) is known to improve
vascular endothelial function in patients at a high risk for cardiovascular (CV) disease. We investigated short-term effects of black raspberry on circulating endothelial progenitor cells (EPCs) and arterial stiffness in patients with metabolic syndrome. Patients with metabolic syndrome (n = 51) were prospectively randomized into the black raspberry group (n = 26, 750 mg/day) and placebo group (n = 25) during the 12-week follow-up. Central blood pressure, augmentation index, and EPCs, such as CD34/KDR(+), CD34/CD117(+), and CD34/CD133(+), were measured at baseline and at 12-week follow-up. Radial augmentation indexes were significantly decreased in the black raspberry group compared to the placebo group (-5% ± 10% vs. 3% ± 14%, P < .05). CD34/CD133(+) cells at 12-week follow-up were significantly higher in the black raspberrygroup compared to the placebo group (19 ± 109/μL vs.
-28 ± 57/μL, P < .05). Decreases from the baseline in interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were significantly greater in the black raspberry group compared to the placebo group (-0.5 ± 1.4 pg/mL vs.
-0.1 ± 1.1 pg/mL, P < .05 and -5.4 ± 4.5 pg/mL vs. -0.8 ± 4.0 pg/mL, P < .05,
respectively). Increases from the baseline in adiponectin levels (2.9 ± 2.1 μg/mL vs.
-0.2 ± 2.5 μg/mL, P < .05) were significant in the black raspberry group. The use of blackraspberry significantly lowered the augmentation index and increased
circulating EPCs, thereby improving CV risks in patients with metabolic syndrome
during the 12-week follow-up.
已知黑 覆盆子（Rubus occidentalis）的施用可改善心血管（CV）疾病高风险患者的血管 内皮功能。我们调查了黑 覆盆子对代谢综合征患者循环内皮祖细胞（EPCs）和动脉僵硬度 的短期影响。代谢综合征患者（N = 51）前瞻性随机进入黑 覆盆子 组（N = 26，750 毫 克/天）和安慰剂组（n = 25）在 12 周的随访期间。在基线和随访 12 周时测量中心血压， 增强指数和 EPCs，如 CD34 / KDR（+），CD34 / CD117（+）和 CD34 / CD133（+）。 桡动脉增强指数均显著中减少黑 覆盆子 组相比，安慰剂组（-5％±10％和 3％±14％，P
<0.05）。与安慰剂组相比，黑 覆盆子 组的 CD34 / CD133（+）细胞在 12 周随访中显着 更高（19±109 /μLvs. -28±57 /μL，P <0.05）。黑覆盆子中白细胞介素-6（IL-6）和肿瘤 坏死因子-α （TNF-α ）的基线下降显着更大 组相比，安慰剂组（-0.5±1.4 皮克/毫升与
-0.1±1.1 皮克/毫升，P <0.05 和-5.4±4.5 皮克/毫升与-0.8±4.0 皮克/毫升，P <0.05 ， 分 别）。从在脂联素水平（2.9±2.1 微克/毫升与-0.2±2.5 微克/毫升，P <0.05）的基线增加 是中显著黑 覆盆子 组。使用黑 覆盆子可显着降低增强指数和增加循环内皮祖细胞数量，从 而改善 12 周随访期间代谢综合征患者的 CV 风险。
doi: 10.1089/jmf.2015.3563
源自：
美国国家医学图书馆
美国国家卫生研究院
US National Library of Medicine/
Us National Institutes of Health/
企业亮照