学术报告 5
Anthocyanins and their role in cancer prevention.
花青素及其在癌症预防中的作用。
原文链接官方网址：https://www.ncbi.nlm.nih.gov/pubmed
Cancer Lett. 2008 Oct 8;269(2):281-90. doi: 10.1016/j.canlet.2008.05.020. Epub 2008
Jun 20.
癌症通讯。2008 年 10 月 8 日; 269（2）：281-90。doi：10.1016 / j.canlet.2008.05.020。 电子书 2008 年 6 月 20 日。
Wang LS1, Stoner GD. Author information
Department of Internal Medicine and Comprehensive Cancer Center, Ohio State
University College of Medicine, Columbus, OH 43210, USA. 王 LS 1，Stoner GD。
俄亥俄州立大学医学院内科及综合癌症中心，美国俄亥俄州 43210，哥伦布市。
Anthocyanins are the most abundant flavonoid constituents of fruits and vegetables. The conjugated bonds in their structures, which absorb light at about 500 nm, are the basis for the bright red, blue and purple colors of fruits and vegetables, as well as the autumn foliage of deciduous trees. The daily intake of anthocyanins in residents of the United States is estimated to be about 200 mg or about 9-fold higher than that of other dietary flavonoids. In this review, we summarize the latest developments on the anti-carcinogenic activities of anthocyanins and anthocyanin-rich extracts in cell culture models and in animal model tumor systems, and discuss their molecular mechanisms of action. We also suggest reasons for the apparent lack of correlation between the effectiveness of anthocyanins in laboratory model systems and in humans as evidenced by epidemiological studies. Future studies aimed at enhancing the absorption of anthocyanins and/or their metabolites are likely to be necessary for their ultimate use for chemoprevention of human cancer.
花青素是水果和蔬菜中最丰富的类黄酮成分。它们的结构中的共轭键吸收了约 500nm 的光， 是水果和蔬菜的鲜红色，蓝色和紫色以及落叶树的秋天叶子的基础。据估计美国居民花青素 的每日摄入量约为 200 毫克或比其他膳食类黄酮高约 9 倍。在这篇综述中，我们总结了细 胞培养模型和动物模型肿瘤系统中花青素和富含花青素的提取物的抗致癌活性的最新进展， 并讨论它们的作用分子机制。我们还建议，由流行病学研究证明，实验室模型系统和人体中 花青素的有效性之间缺乏相关性的原因。旨在增强花青素和/或其代谢物吸收的未来研究可 能是它们最终用于化学预防人类癌症的必要条件。
doi：10.1016 / j.canlet
源自：
美国国家医学图书馆
美国国家卫生研究院
US National Library of Medicine/
Us National Institutes of Health/
企业亮照