学术报告 6
Laboratory and clinical studies of cancer chemoprevention
by antioxidants in berries. 癌症化学预防的抗氧化剂在浆果的实验室和临床研究。
原文链接官方网址：https://www.ncbi.nlm.nih.gov/pubmed
Carcinogenesis. 2008 Sep;29(9):1665-74. doi: 10.1093/carcin/bgn142. Epub 2008
Jun 9.
致癌作用。2008 年 9 月; 29（9）：1665-74。doi：10.1093 / carcin / bgn142。电子书 2008 年 6 月 9 日。
Stoner GD1, Wang LS, Casto BC. Author information
Department of Internal Medicine, College of Medicine, The Ohio StateUniversity,
Columbus, OH 43210, USA. gary.stoner@osumc.edu
俄亥俄州立大学医学 院内科医 学 系 ， 美 国 俄 亥 俄 州 43210 ， 哥 伦 布 市 。
Reactive oxygen species (ROS) are a major cause of cellular injury in an increasing number of diseases, including cancer. Most ROS are created in the cell through normal cellular metabolism. They can be produced by environmental insults such as
ultraviolet light and toxic chemicals, as well as by the inflammatory process.
Interception of ROS or limiting their cellular effects is a major role of antioxidants. Due to their content of phenolic and flavonoid compounds, berries exhibit high antioxidant potential, exceeding that of many other foodstuffs. Through their ability to scavenge ROS and reduce oxidative DNA damage, stimulate antioxidant enzymes, inhibit carcinogen-induced DNA adduct formation and enhance DNA repair, berry compounds have been shown to inhibit mutagenesis and cancer initiation. Berry constituents also influence cellular processes associated with cancer progression including signaling pathways associated with cell proliferation, differentiation, apoptosis and angiogenesis. This review article summarizes laboratory and human studies, demonstrating the protective effects of berries and berry constituents on oxidative and other cellular processes leading to cancer development.
活性氧（ROS）是越来越多的疾病（包括癌症）中细胞损伤的主要原因。大多数 ROS 是通 过正常的细胞代谢在细胞中产生的。它们可以通过环境污染如紫外线和有毒化学物质以及炎 症过程产生。截留 ROS 或限制其细胞效应是抗氧化剂的主要作用。由于它们含有酚类和类 黄酮化合物，浆果具有很高的抗氧化潜力，超过许多其他食品。通过它们清除 ROS 并减少 氧化 DNA 损伤，刺激抗氧化酶，抑制致癌物诱导的 DNA 加合物形成和增强 DNA 修复的 能力，浆果化合物已显示抑制诱变和癌症发作。浆果组分也影响与癌症进展有关的细胞过程， 包括与细胞增殖，分化，凋亡和血管生成相关的信号传导途径。这篇综述文章总结了实验室 和人类研究，展示了浆果和浆果成分对导致癌症发展的氧化和其他细胞过程的保护作用。
doi：10.1093 / carcin / bgn142
源自：
美国国家医学图书馆
美国国家卫生研究院
US National Library of Medicine/
Us National Institutes of Health/
企业亮照