学术报告 8
Cancer prevention with freeze-dried berries and berry
components. 用冻干浆果和浆果成分预防癌症。
原文链接官方网址：https://www.ncbi.nlm.nih.gov/pubmed
Stoner GD1, Wang LS, Zikri N, Chen T, Hecht SS, Huang C, Sardo C, Lechner JF.
Division of Hematology and Oncology, Department of Internal Medicine, College of
Medicine, The Ohio State University, Innovation Centre, 2001 Polaris Parkway, Columbus, OH 43240, USA. gary.stoner@osumc.edu
Stoner GD 1，Wang LS，Zikri N，Chen T，Hecht SS，Huang C，Sardo C，Lechner JF。
美国俄亥俄州立大学医学院血液与肿瘤学系，创新中心，2001 Polaris Parkway，Columbus，
OH 43240，美国。gary.stoner@osumc.edu
Our laboratory is developing a food-based approach to the prevention of
esophageal and colon cancer utilizing freeze-dried berries and berry extracts. Dietary freeze-dried berries were shown to inhibit chemically induced cancer of the rodent esophagus by 30-60% and of the colon by up to 80%. The berries are effective at both the initiation and promotion/progression stages of tumor development. Berries inhibit tumor initiation events by influencing carcinogen metabolism, resulting in reduced levels of carcinogen-induced DNA damage. They inhibit promotion/progression events by reducing the growth rate of pre-malignant cells, promoting apoptosis, reducing parameters of tissue inflammation and inhibiting angiogenesis. On a molecular level, berries modulate the expression of genes involved with proliferation, apoptosis, inflammation and angiogenesis. We have recently initiated clinical trials; results from a toxicity study indicated that freeze-dried black raspberries are well tolerated in humans when administered orally for 7 days at a dose of 45 g per day. Several Phase IIa clinical trials are underway in patients at high risk for esophagus and colon cancer; i.e., Barrett's esophagus, esophageal dysplasia and colonic polyps, to determine if berries will modulate various histological and molecular biomarkers of development of these diseases.
我们的实验室正在开发一种基于食物的方法，以利用冻干浆果和浆果提取物预防食道癌和结 肠癌。显示饮食性冻干浆果能够抑制化学诱导的啮齿动物食道癌 30-60％，结肠癌高达 80％。 浆果在肿瘤发生的起始和促进/发展阶段均有效。浆果通过影响致癌物代谢来抑制肿瘤起始 事件，导致致癌物诱导的 DNA 损伤水平降低。它们通过降低恶化前细胞的生长速度，促进 细胞凋亡，降低组织炎症参数和抑制血管生成来抑制促进/进展事件。在分子水平上，浆果 调节涉及增殖，细胞凋亡，炎症和血管生成的基因的表达。我们最近开始临床试验; 毒性研 究结果表明冻干当以 45g /天的剂量口服给药 7 天时，黑覆盆子在人体内耐受性良好。在食 管和结肠癌高危患者中正在进行几项 IIa 期临床试验; 即巴雷特食管，食管发育不良和结肠 息肉，以确定浆果是否会调节这些疾病发展的各种组织学和分子生物标志物。
源自：
美国国家医学图书馆
美国国家卫生研究院
US National Library of Medicine/
Us National Institutes of Health/
企业亮照