学术报告 2
Black raspberries in cancer clinical trials: Past, present and future.
癌症临床试验中的黑覆盆子：过去，现在和未来。
原文链接官方网址：https://www.ncbi.nlm.nih.gov/pubmed
Kresty LA 1，Mallery SR 2，Stoner GD 1。
1 Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
2 Division of Oral and Maxillofacial Pathology and Radiology, College of Dentistry, The Ohio State University, Columbus, OH, USA.
1 美国威斯康星州密尔沃基市威斯康星医学院血液和肿瘤学系医学系。
2 美国俄亥俄州立大学俄亥俄州立大学牙科学院口腔和颌面部病理和放射学部门。
BACKGROUND:
Black raspberries (BRB) inhibit a broad range of cancers in preclinical models, including in vivo models of oral, esophageal, colon, breast and skin cancer.
Promising preclinical results have led to clinical evaluations in cancer patients or patients at increased risk for cancer development.
背景： 黑覆盆子（BRB）在临床前模型中抑制广泛的癌症，包括口腔，食管，结肠，乳房和皮 肤癌的体内模型。有希望的临床前结果已导致癌症患者或癌症发展风险增加的患者的临 床评估。
OBJECTIVE:
To summarize clinical investigations targeting cancer or precancerous lesions
with BRB and discuss future directions.
目的：
总结用 BRB 治疗癌症或癌前病变的临床研究并讨论未来的方向。
METHODS:
A thorough literature search was conducted through December 1, 2015 to identify all published studies evaluating BRB in cancer focused clinical trials.
方法：
在 2015 年 12 月 1 日前进行了彻底的文献检索，以确定所有已发表的评估 BRB 肿瘤专 题临床试验的研究。
RESULTS:
Research investigating BRB in clinical settings report positive effects on preneoplastic lesions or cancers of the oral cavity, esophagus and colon. BRB treatment resulted in: histologic regression of oral intraepithelial neoplasia associated with improved histologic grade and significantly reduced loss of heterozygosity at tumor suppressor gene loci, modulated genes linked to RNA processing and growth factor recycling; in the colon, BRB inhibited
FAP-associated polyp progression, demethylated tumor suppressor genes and improved plasma cytokine profiles; in Barrett's patients, BRB consumption increased tissue levels of GST-pi and decreased 8-isoprostane, a marker of lipid peroxidation/oxidative stress.
在临床环境中调查 BRB 的研究报告对癌前病变或口腔癌，食道癌和结肠癌有正面影响。
BRB 治疗导致：口腔上皮内瘤变的组织学消退与组织学分级的改善相关联，并显着降低 肿瘤抑制基因位点处的杂合性丢失，调节的基因与 RNA 加工和生长因子再循环相关; 在 结肠中，BRB 抑制 FAP 相关息肉进展，去甲基化肿瘤抑制基因和改善的血浆细胞因子 谱; 在 Barrett 患者中，BRB 消耗增加了 GST-pi 的组织水平并降低了脂质过氧化/氧化 应激的标记物 8-异前列烷。
CONCLUSIONS:
The precise dose, duration and optimum mode of BRB delivery for cancer inhibition remains to be fully elucidated. Common themes across studies support that BRB are anti-proliferative, anti- inflammatory, reduce oxidative stress and restore tumor suppressive activity. Future directions are included in the conclusions section.
结论：
BRB 递送用于癌症抑制的精确剂量，持续时间和最佳模式仍有待完全阐明。各研究的共 同主题支持 BRB 具有抗增殖，抗炎，减少氧化应激和恢复肿瘤抑制活性。未来方向包 含在结论部分。
PMID:27594930
源自：
美国国家医学图书馆
美国国家卫生研究院
US National Library of Medicine/
Us National Institutes of Health/
企业亮照