学术报告 10
Pharmacokinetics of anthocyanins and ellagic acid in
healthy volunteers fed freeze-dried blackraspberries daily for 7 days.
花青素和鞣花酸在健康志愿者中的药代动力学每天喂食冷冻干燥的 黑覆盆子 7 天。
原文链接官方网址：https://www.ncbi.nlm.nih.gov/pubmed
J Clin Pharmacol. 2005 Oct;45(10):1153-64.
Stoner GD1, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V, Singh A, Sanders
Division of Hematology/Oncology, Department of Internal Medicine, College of
Medicine, The Ohio State University, 1148 James CHRI, 300 W 10th Avenue, Columbus, OH 43210, USA.
斯通 GD 1，Sardo 的 Ç，Apseloffģ，鲻鱼 d，Wargo w ^，磅 V，辛格甲，桑德斯 Ĵ，阿
美国俄亥俄州立大学医学院血液学/肿瘤学系，1148 James CHRI，美国俄亥俄州 43210，
哥伦布市第 10 大道 300 号。
Eleven subjects completed a clinical trial to determine the safety/tolerability of
freeze-dried black raspberries (BRB) and to measure, in plasma and urine, specific
anthocyanins-cyanidin-3-glucoside,cyanidin-3-sambubioside,
cyanidin-3-rutinoside, and cyanidin-3-xylosylrutinoside, as well as ellagic acid. Subjects were fed 45 g of freeze-dried BRB daily for 7 days. Blood samples were collected predose on days 1 and 7 and at 10 time points postdose. Urine was collected for 12 hours predose on days 1 and 7 and at three 4-hour intervals postdose. Maximum concentrations of anthocyanins and ellagic acid in plasma occurred at 1 to 2 hours, and maximum quantities in urine appeared from 0 to 4 hours. Overall, less than 1% of these compounds were absorbed and excreted in urine. None of the pharmacokinetic parameters changed significantly between days 1 and 7. In conclusion, 45 g of freeze-dried BRB daily are well tolerated and result in quantifiable anthocyanins and ellagic acid in plasma and urine.
十一名受试者完成了一项临床试验，以确定冻干黑色的安全性/耐受性覆盆子（BRB），并在 血浆和尿液中测量特定的花青素 - 花青素-3-葡萄糖苷，矢车菊素-3-桑布比苷，矢车菊素-3-芸香糖苷和矢车菊素-3-木糖基芸香糖苷以及鞣花酸。受试者每天喂食 45g 冻干 BRB， 持续 7 天。在第 1 天和第 7 天以及在给药后 10 个时间点收集血液样品。在第 1 天和第 7天以及在给药后三个 4 小时收集尿液 12 小时。血浆中花青素和鞣花酸的最大浓度发生在 1至 2 小时，尿中最大量出现在 0 至 4 小时。总体而言，这些化合物中少于 1％被吸收并在尿液中排泄。在第 1 天和第 7 天之间，没有任何药代动力学参数发生显着变化。
源自：
美国国家医学图书馆
美国国家卫生研究院
US National Library of Medicine/
Us National Institutes of Health/
企业亮照