学术报告 1

Therapeutic Effects of Anthocyanins for Vision and Eye Health

花青素对视力和眼部健康的治疗作用

原文链接官方网址：https://www.ncbi.nlm.nih.gov/pubmed

Molecules. 2019 Sep 11;24(18):3311.  doi: 10.3390/molecules24183311.

Abstract

Anthocyanin (AC) is widely used as supplement of eye health in Europe and in East Asia. In this review, I describe AC effects to clarify the mechanism is important in order to understand the effects of AC on vision health. The bioavailability of AC is quite low but, reported as intact form and many kinds of metabolite. And AC passes through the blood-aqueous fluid barrier and blood-retinal barrier. In vitro study, AC had a relaxing effect on ciliary muscle which is important to treat both myopia and glaucoma. And AC stimulate the regeneration of rhodopsin in frog rod outer segment. Furthermore, AC could inhibit the axial length and ocular length elongation in a negative lens-induced chick myopia model. In addition, we summarized clinical studies of AC intake improved dark adaptation and transient myopic shift and the improvement on retinal blood circulation in normal tension glaucoma patients.

摘要 花青素(下文简称：AC)在欧洲和东亚被广泛用作眼部健康的补充。在这篇综述中，我描述 AC效应，以阐明AC的作用机制对于了解AC对视力健康的影响是非常重要的。AC的生物利 用度很低，但据报道为完整的形态和多种代谢物。AC通过血水液屏障和血视网膜屏障。在 体外研究中，AC对睫状肌有舒张作用，对近视和青光眼的治疗均有重要意义。AC刺激蛙杆 外段视紫红质的再生。AC还能抑制负性晶状体诱导的鸡近视模型的轴长和眼长。此外，我 们还总结了AC摄入改善正常眼压性青光眼患者暗适应和暂时性近视转移以及改善视网膜血 液循环的临床研究。

Keywords: anthocyanin; blood circulation; ciliary muscle; glaucoma; myopia.

关键词：花青素；血液循环；睫状肌；青光眼；近视。

Molecules. 2019 Sep; 24(18): 3311.

Published online 2019 Sep 11. DOI: 10.3390/molecules24183311

PMID: 31514422

Yuri Nomi,1 Keiko Iwasaki-Kurashige,2 and Hitoshi Matsumoto1,

源自：

美国国家医学图书馆

美国国家卫生研究院

US National Library of Medicine/

Us National Institutes of Health/