学术报告 3

Recent research on polyphenolics in vision and eye health

多酚类物质（生物类黄铜）在视力和眼睛健康方面的研究进展

原文链接官方网址：https://www.ncbi.nlm.nih.gov/pubmed

J Agric Food Chem. 2010 Apr 14;58(7):4001-7.  doi: 10.1021/jf903038r.

Abstract

A long-standing yet controversial bioactivity attributed to polyphenols is their beneficial effects in vision. Although anecdotal case reports and in vitro research studies provide evidence for the visual benefits of anthocyanin-rich berries, rigorous clinical evidence of their benefits is still lacking. Recent in vitro studies demonstrate that anthocyanins and other flavonoids interact directly with rhodopsin and modulate visual pigment function. Additional in vitro studies show flavonoids protect a variety of retinal cell types from oxidative stress-induced cell death, a neuroprotective property of significance because the retina has the highest metabolic rate of any tissue and is particularly vulnerable to oxidative injury.

However, more information is needed on the bioactivity of in vivo conjugates and the accumulation of flavonoids in ocular tissues. The direct and indirect costs of age-related vision impairment provide a powerful incentive to explore the potential for improved vision health through the intake of dietary polyphenolics.

摘要 一个长期存在，但有争议的生物活性物质——多酚类物质（生物类黄铜），在视觉保护上， 他们的起到了积极的有益作用。尽管案例报告和体外研究为富含花青素的浆果的视觉效果提 供了证据，但对其益处的严格临床证据仍然缺乏。最近的体外研究表明，花青素和其他黄酮

类化合物直接与视紫红质相互作用，调节视色素的功能。此外，体外研究表明，黄酮类化合

物可以保护多种类型的视网膜细胞免受氧化应激诱导的细胞死亡，这是一种具有重要意义的 神经保护特性，因为视网膜是任何组织中代谢率最高的组织，尤其容易受到氧化损伤。然而

，在体内结合物的生物活性和眼组织中黄酮类化合物的积累方面还需要更多的信息。与年龄 相关的视力损害的直接和间接成本提供了一个强有力的动机，以探索通过饮食多酚类物质的 摄入改善视力健康的潜力。

Agric Food Chem. 2010 Apr 14;58(7):4001-7. Authors

Wilhelmina Kalt 1 , Anne Hanneken, Paul Milbury, Francois Tremblay Affiliation

1 Atlantic Food and Horticulture Research Centre, Agriculture and Agri- Food Canada, Kentville, Nova Scotia, Canada. wilhelmina.kalt@agr.gc.ca PMID: 20102149

DOI: 10.1021/jf903038r

源自：

美国国家医学图书馆

美国国家卫生研究院

US National Library of Medicine/

Us National Institutes of Health/