学术报告 3
Effects of Rubus occidentalis extract on blood pressure in patients with prehypertension: Randomized,
double-blinded, placebo-controlled clinical trial.
黑覆盆子提取物对高血压前期患者血压的影响：随机，双盲，安慰剂 对照临床试验。
原文链接官方网址https://www.ncbi.nlm.nih.gov/pubmed/
Nutrition. 2016 Apr;32(4):461-7. doi: 10.1016/j.nut.2015.10.014. Epub 2015 Nov 6.
营养。2016 年 4 月; 32（4）：461-7。doi：10.1016 / j.nut.2015.10.014。电子书 2015 年 11
月 6 日。
Jeong HS1, Hong SJ2, Cho JY1, Lee TB3, Kwon JW3, Joo HJ1, Park JH1, Yu CW1, Lim
DS1.
Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital,
Seoul, Korea.
Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Seoul, Korea. Electronic address: psyche94@gmail.com.
Gochang Black Raspberry Research Institute, Gochang-gun, Korea.
韩国首尔韩国大学 Anam 医院心血管中心心内科。
韩国首尔韩国大学 Anam 医院心血管中心心内科。电子地址：psyche94@gmail.com。
高敞黑树莓研究所，韩国高敞郡。
Abstract
OBJECTIVE:
Black raspberry (Rubus occidentalis) is known for improving vascular function. However, there has been no study evaluating its effects on 24-h systolic and diastolic blood pressure in prehypertensive patients. The aim of this study was to examine those effects.
目的：
黑覆盆子（Rubus occidentalis）以改善血管功能而闻名。然而，尚未有研 究评估其对高血压前期患者 24 小时收缩压和舒张压的影响。这项研究的目的 是检查这些影响。
METHODS:
Patients with prehypertension (N = 45) were prospectively randomized into a moderate-dose black raspberry group (n = 15, 1500 mg/d), a high-dose black raspberry group (n = 15, 2500 mg/d), or a placebo group (n = 15) during an 8-wk follow-up period. Raspberries were consumed in the form of a dried powder extract that was fashioned into capsules. The capsules contained 187.5 and 312.5 mg of raspberry powder, which was equivalent to 1500 and 2500 mg raspberries.
Ambulatory 24-h blood pressure (BP); central BP; pulse-wave velocity; abdominal visceral fat; serum renin; angiotensin-converting enzyme; and inflammatory
plasminogen activator inhibitor-1 were measured at baseline and at 8-wk
follow-up.
方法：
患者高血压前期（N = 45）进行前瞻性随机分为中等剂量黑覆盆子组（n = 15， 1500 毫克/ d），高剂量黑覆盆子组（n = 15，2500 毫克/ d）或安慰剂组
（n = 15）在 8 周的随访期间。树莓被制成胶囊形式的干粉提取物被食用。 胶囊含有 187.5 和 312.5 毫克覆盆子粉，相当于 1500 和 2500 毫克覆盆子。 动态 24 小时血压（BP）; 中央 BP; 脉搏波速度; 腹部内脏脂肪; 血清肾素; 血 管紧张素转换酶; 和炎症因子如白细胞介素-6，肿瘤坏死因子-α，C-反应蛋 白，可溶性细胞间粘附分子-1，可溶性血管细胞粘附分子-1，
RESULTS:
High-dose black raspberry significantly reduced 24-h systolic blood pressure (SBP;
3.3 ± 10 mm Hg versus -6.7 ± 11.8 mm Hg; P < 0.05) and nighttime SBP (5.4 ± 10.6 mm Hg versus -4.5 ± 11.3 mm Hg; P < 0.05) compared with controls during the
8-wk follow-up. Black raspberry powder did not produce any significant changes in most of the parameters other than BP.
高剂量黑覆盆子显着降低 24 小时收缩压（SBP; 3.3±10mmHg 相对于
-6.7±11.8mmHg; P<0.05）和夜间 SBP（5.4±10.6mmHg 相对于
-4.5±11.3mmHg;与对照组相比，在 8 周的随访中 P<0.05）。除了 BP 以
外，黑覆盆子粉在大多数参数中没有产生任何显着变化。
CONCLUSION:
The use of black raspberry significantly lowered 24-h BP in prehypertensive patients during the 8-wk follow-up. Black raspberry used as a dietary supplement could be beneficial in reducing SBP in prehypertensive patients.
Copyright © 2016 Elsevier Inc. All rights reserved.
结论：
在 8 周的随访期间，使用黑覆盆子显着降低了高血压前期患者的 24 小时血 压。用作膳食补充剂的黑覆盆子可能有利于降低高血压前期患者的 SBP。
PMID:26740254
DOI: 10.1016/j.nut.2015.10.014
源自：
美国国家医学图书馆
美国国家卫生研究院
US National Library of Medicine/
Us National Institutes of Health/
企业亮照